"Depressed individuals typically show poor memory for positive events, potentiated memory for negative events, and impaired recollection. These phenomena are clinically important but poorly understood. Compelling links between stress and depression suggest promising candidate mechanisms. Stress can suppress hippocampal neurogenesis, inhibit dopamine neurons, and sensitize the amygdala. We argue that these phenomena may impair pattern separation, disrupt the encoding of positive experiences, and bias retrieval towards negative events, respectively, thus recapitulating core aspects of memory disruption in depression. Encouragingly, optogenetic reactivation of cells engaged during the encoding of positive memories rapidly reduces depressive behavior in preclinical models. Thus, many memory deficits in depression appear to be downstream consequences of chronic stress, and addressing memory disruption can have therapeutic value."

"​Depression is a serious mental condition affecting the individual’s mood, feelings, thoughts and well being. There are several effects of depression on the brain. For example, your patterns of appetite and sleep. They would be unable to experience in pleasure in any activities and would possess a sense of hopelessness, helplessness, and worthlessness. These are all the observable changes in an individual with clinical depression. These changes are are just some ways how depression affects the brain.  "

"​​Mental was created by Bobby Temps to break down mental health stigma and discrimination. Each week joined by a special guest, the podcast is a safe space to hear honest and insightful mental health interviews in the hope listeners will feel more empowered to continue the conversation with others."

Trans Lifeline is a trans-led organization that connects trans people to the community, support, and resources they need to survive and thrive.

If you are thinking about harming yourself — get immediate crisis support. Connect to a crisis counselor 24/7, 365 days a year, from anywhere in the U.S via text, chat, or phone. The Trevor Project is 100% confidential and 100% free.

The 988 Lifeline is a national network of local crisis centers that provides free and confidential emotional support to people in suicidal crisis or emotional distress 24 hours a day, 7 days a week in the United States.

Addresses individuals coping with non-suicidal self-injury, including locally-based information, support and therapy referrals.

I used graph paper to create my pattern layout for weaving text with 1”x 50” mylar and cellophane strips in I Love This Color. Each square will represent the thickness of your material.